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57.  Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues Breunig, J. L.; Valdes-Pena, M. A.; Ratchford, A. W.; Pierce, J. G. ACS Bio. Med. Chem. Au 2024In Press.


56.  Expanded Library of Novel 2,3-Pyrrolidinedione Analogues Exhibit Antibiofilm Activity Nie, M.; Valdes-Pena, M. A.; Frohock, B. H.; Smits, E.; Daiker, J. C.; Gilbertie, J. M.; Schnabel, L. V.; Pierce, J. G. Bioorg. Med. Chem. Lett. 2024, In Press. 



55.  Photoredox catalyzed C(sp3)-C(sp3) coupling of α-bromoesters and triethylamine Guerra, A. W.; Pierce, J. G. J. Org. Chem. 2023, In Press. 


  1. Recent Advances in the Discovery of Antimicrobial Natural Products Through Synthetic Means Valdes-Pena, M. A.; Pierce, Joshua G. ACS Med Chem Rev 2023, 315-343.

53. Total Synthesis of Bipolamine I Qiu, X.; Pierce, J. G. J. Am. Chem. Soc. 2022, 144, 12638.


52. Tissue-Reactive Drugs Enable Materials-Free Local Depots Pandit, S.; Palvai, S. K.; Massaro, N.P.; Pierce, J. G.; Brudno, Y. J. Cont. Rel. 2022, 323, 142.


51. Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture. Moody, C.; Brown, A.; Massaro, N. P.; Patel, A.; Zheng, H.; Pierce, J.G.; Brudno, Y. Acta Biomaterialia 2022, 138, 208.


50. Synthesis of the Spirocyclic g-Lactam Core of the Ansalactams. Liang, Z.; Lin, Y-C.; Pierce, J. G. Org. Lett. 2021, 23, 9559.


49. Rapid Synthesis of the Core Scaffold of Crinane and Haemanthamine through a Multi-Component Approach. Massaro, N. P.; Pierce, J. G. Tetrahedron Lett2021In Press. (Invited Submission in honor of Dale L. Boger’s Tetrahedron Prize for Creativity in Organic Chemistry)


48. Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence. Valdes-Pena, M. A.; Massaro, N. P.; Lin Y. C.; Pierce, J. G. Acc. Chem. Res. 2021, 54, 1866.


47. Design, synthesis, and evaluation of substrate – analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B. Gonzalez, S. N; Mills, J. J.; Maugeri, D.; Olaya, C.; Laguera, B. L.; Enders, J. R.; Sherman, J.; Rodriguez, A.; Pierce, J. G.; Cazzulo, J. J.; D’Antonio, E. L. Bioorg. Med. Chem. Lett. 2021, 32, 127723.

46. Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds. Massaro, N. P.; Pierce, J. G. Org. Lett., 202022, 5079.


45. Genetic Determinants of Salmonella Resistance to the Anti-Biofilm Effects of a Synthetic 4-Oxazolidinone Analog. Griewisch, K. F.; Pierce, J. G.; Elfenbein, J. R. Appl. Environ. Microbiol. 2020, 86, e01120-20.


44. Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent StrategyLin, Y.-C.; Ribaucourt, A.; Moazami, Y.; Pierce, J. G. J. Am. Chem. Soc., 2020, 142, 9850.


43. Stereocontrolled Synthesis of Melokhanine E via an Intramolecular Formal [3+2] Cycloaddition. Cholewczynski, A. E.; Williams, P. C.; Pierce, J. G. Org. Lett. 202022, 714. ChemRxiv preprint:


42. 5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms. Frohock, B.; Gilbertie, J. M.; Daiker, J. C.; Schnabel, L. V.; Pierce, J. G. ChemBioChem, 2020, 21, 933. VIP Paper and Journal Cover. ChemRxiv Preprint:


41. Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. Robinson, K.; Mills, J. J.; Pierce, J. G. ACS Med. Chem. Lett., 2019, 10, 374. ChemRxiv preprint:

40. Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays. Martinez-Brokaw, C. D.; Radke, J. B.; Pierce, J. G.; Ehlers, A.; Ekins, S.; Wood, K. E.; Maakestad, J.; Rymer, J. A.; Tamama, K.; Krasowski, M. D. BMC Clin. Path. 2019, 19, 2.

39. In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation. Luckring, E. J.; Parker, P. D.; Hani, H.; Grace, M. H.; Lila, M. A.; Pierce, J. G.; Adin, C. A. Cell Transplant 2020, 29, 1.

38. Synthesis and Biological Activity of Lipoxazolidinone A. Mills, J. J.; Robinson, K.; Zehnder, T. E.; Pierce, J. G. Angew. Chem. Int. Ed. 2018, 130, 8818.


37. 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as Novel Antibacterial Scaffolds Against Methicillin-Resistant Staphlyococcus aureus Cusumano, A. Q.; Pierce, J. G. Bioorg. Med. Chem. Lett. 2018, 28, 2732. (Invited Submission for issue in Honor of Dale L. Boger).


36. Coupling of Thioamides with 4-Bromoacrotonate Esters and Subsequent Conjugate Addition for the Rapid One-Pot Synthesis of Functionalized Thiazolines. Parker, P. D.; Ge, Y.; Pierce, J. G. Tetrahedron Lett., 2018, 59, 277.


35. Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts. Parker, P. D.; Lemercier, B. C.; Pierce, J. G. J. Org. Chem. 2018, 83, 12 (Featured Article & Front Cover).


34. Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide. Gulledge, T. V.; Collette, N. M.; Moazami, Y.; Juzumaite, M.; Tong, S.; Mackey, E.; Moeser, A. J.; Pierce, J. G.; Cech, N. B.; Laster, S. M. J Ethnopharmacol. 2018, 212, 166.

33. Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and alpha-Oxoesters. Cusumano, A. Q.; Boudreau, M. W.; Pierce, J. G. J. Org. Chem. 2017, 82, 13714.

32. 5-Benzylidene-4-oxazolidinones Potently Inhibit Biofilm Formation in Methicillin-Resistant Staphylococcus aureus. Edwards, G. A.; Shymanska, N. V.; Pierce, J. G. Chem. Commun. 2017, 53, 7353. (Invited Submission for Emerging Investigators Issue)

31. Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids. Shymanska, N. V.; Pierce, J. G. Org. Lett. 2017, 19, 2961.

30. Structure, Synthesis and Biological Properties of the Pentacyclic Gaunidinium Alkaloids. Shi, Y.; Moazami, Y. M.; Pierce, J. G. Bioorg. Med. Chem. 2017, 25, 2817. (Invited Submission in honor of Xiaoguang Lei).

29. How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar! Pierce, J. G. Cell Chem. Biol. 2017, 24, 121. (Invited Preview)

28. Stereocontrolled Synthesis of Plagiogyrin A. Shi, Y.; Pierce, J. G. Org. Lett. 2016, 18, 5308.

27. Examining Ubiquitinated Peptide Enrichment Efficiency through an Epitope Labeled Protein.  Parker, J. L.; Oh, Y. Y.; Moazami, Y.; Pierce, J. G.; Dean, R. A; Muddiman, D. C. Anal. Biochem. 2016, 512, 114.

26. Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes.  Parker, P. D.; Pierce, J. G. Synthesis 2016, 48, 1902. Invited Special Topics Article for “Cyclization Tactics and Strategies”

25. Thiohydroximic Acids: Versatile Reagents for Organic Synthesis.  Lemercier, B. C.; Pierce, J. G Synlett 2015, 27, 181. Invited SYNPACT perspective.

24. Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2015, 17, 4542.

23. Synthesis and Biological Evaluation of a Series of Fatty Acid Amides from Echinacea.  Moazami, Y.; Gulledge, T.; Laster, S. M.; Pierce, J. G. Bioorg. Med. Chem. Lett. 2015, 25, 3091.

22. Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines. Moazami, Y.; Pierce, J. G. Synthesis 2015 47, 3363.

21. Rapid Synthesis and Antimicrobial Activity of Novel 4-Oxazolidinone Heterocycles. Shymanska, N. V.; An, I. H.; Guevara-Zuluaga, S.; Pierce, J. G. Bioorg. Med. Chem. Lett. 2015, 25, 4887.  Invited submission to 25th Anniversary Issue.

20. Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A. Shi, Y.; Pierce, J. G. Org. Lett. 2015, 17, 968.

19. A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B. Shymanska, N. V.; An, I. H.; Pierce, J. G. Angew. Chem. Int. Ed. 2014, 53, 5401.

18. Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2014, 16, 2074.

17. Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives. Lemercier, B. C.; Pierce, J. G. J. Org. Chem. 2014, 79, 2321.

16. Synthesis of a Library of Tricyclic Azepinoisoindolinones. Miller, B.; Mao, S.; Rosenker, K. M. G.; Pierce, J. G.; Wipf, P. Beilstein J. Org. Chem. 2012, 8, 1091.

15. Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines that Clarify Binding Behavior to Model Ligands. Okano, A.; James, R. C.; Pierce, J. G.; Xie, J.; Boger, D. L. J. Am. Chem. Soc. 2012, 134, 8790.

14. Redesign of Glycopeptide Antibiotics – Back to the Future. James, R. C.; Pierce, J. G.; Okano, A.; Xie, J.; Boger, D. L. ACS Chemical Biology, 2012, 7, 000.

13. Total Synthesis of [Ψ[C(=S)NH]Tpg4]Vancomycin Aglycon, Ψ[C(=NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding. Xie, J.; Okano, A.; Pierce, J. G.; James, R. C.; Stamm, S.; Crane, C.; Boger, D. L. J. Am. Chem. Soc. 2012, 134, 1284.

12. A Redesigned Vancomycin Engineered for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria. Xie, J.; Pierce, J. G.; James, R. C.; Okano, A.; Boger, D. L. J. Am. Chem. Soc. 2011, 133, 13946.

11. Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs. Frantz, M-C.; Pierce, J. G.; Pierce, J. M.; Kangying, L.; Qingwei, W.; Johnson, M.; Wipf, P. Org. Lett. 2011, 13, 2318.

10. Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon. Crane, C. M.; Pierce, J. G.; Leung, S. S. F.; Tirado-Rives, J.; Jorgensen, W. L.; Boger, D. L. J. Med. Chem. 2010, 53, 7229.

9. The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair. Rajagopalan, M. S.; Gupta, K.; Epperly, M. W.; Franicola, D.; Zhang, X.; Wang, H.; Zhao, H.; Tyurin, V. A.; Pierce, J. G.; Kagan, V. E.; Wipf, P.; Kanai, A.; Greenberger, J. S. In Vivo 2009, 23, 717.

8. Synthesis of Hydroxylated L-Choi derivatives from L-Tyrosine: Octahydro-1H-indole Carboxylates. Wipf, P.; Pierce, J. G.; Fushimi, M.; Kasi, D.; Cuzzupe, A. J. Org. Chem. 2008, 73, 7807.

7. Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions. Pierce, J. G.; Waller, D. L.; Wipf, P. J. Organometallic Chem. 2007, 692, 4618.

6. Expedient Synthesis of the aC-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000). Wipf, P.; Pierce, J. G. Org. Lett. 2006, 8, 3375.

5. Synthesis of Homoallylic Amines by Hydrozirconation-Imine Addition of Allenes. Wipf, P.; Pierce, J. G. Org. Lett. 2005, 7, 3537.

4. Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of αC-Glycosides. Wipf, P.; Pierce, J. G.; Zhuang, N. Org. Lett. 2005, 7, 483.

3. Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl-Mesulate and (P)-1-Tributylstannyl-1,2-Butadiene. Marshall, J. A.; Chobanian, H. Checked by Wipf, P.; Pierce, J. G. Org. Synth. 2005, 82, 43.

2. Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst. Motoyama, Y.; Itonaga, C.; Ishida, T.; Takasaki, M.; Nagashima, H. Checked by Wipf, P.; Pierce, J. G. Org. Synth. 2005, 82, 188.

1. Investigation of Ligand Loading and Asymmetric Amplification in CHAOx-Catalyzed Diethylzinc Additions. Wipf, P.; Pierce, J. G.; Wang, X. Tetrahedron: Asymmetry (Special Issue on Asymmetric Syntheses on a Process Scale) 2003, 14, 3605.